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Mammalian V-ATPase in a native synaptic vesicle
Structure obtained from direct imaging of native synaptic vesicles
Mycobacterial respiratory supercomplex with bound Mqo
Structure of the mycobacterial respiratory supercomplex in a native lipid bilayer shows bound malate:quinone oxidoreductase
ATP synthase
'Mosaic model' of the intact mitochondrial ATP synthase
Mammalian V-ATPase in a native synaptic vesicle
Structure obtained from direct imaging of native synaptic vesicles
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Who we are
Our group, consisting of biophysicists and biochemists, studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, biochemistry and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist.
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